MANNA - project 04
04gb sk

Protein synthesis rates, effect of diet, health and innate immune responses in chicken

Prof. Tom Preston
University of Glasgow
https://www.gla.ac.uk/
Prof. Mangesh Bhide
University of Veterinary Medicine and Pharmacy in Kosice
http://www.uvlf.sk/en
University of Zagreb
http://www.unizg.hr/homepage/
Dr. Chris Chadwick
Life Diagnostics (UK)
https://lifediagnostics.com/

MetLabs (Slovak Republic)
http://metlabs.sk/

TAGS: Fractional Synthesis Rate; deuterium oxide; chickens;

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Objectives

The aim of the project is to determine the rate of protein synthesis in tissues of chicken following endotoxin challenge and the effect of diet on this response.

Description of the project

The Early Stage Researcher (ESR) will study the fractional synthesis rate (FSR) of multiple target proteins in tissues from broiler chickens and assess the effects of using natural immunomodulatory compounds as supplements in their diet to the FSR under challenge by bacterial endotoxin. The ESR will focus on determining the FSR of selected target proteins by supplementing the diets with deuterium oxide (2H2O) and determining FSR by gas chromatography and mass spectrometry. The analytical spectrum will then be extended to OMIC analysis on selective proteins such as ovotransferrin, myosin, albumin and other plasma proteins with their relative synthesis rates determined during endotoxin challenge.

The ESR will be enrolled in the University of Glasgow (https://www.gla.ac.uk/) under the supervision of Professor Tom Preston, Scottish Universities Environmental Research Centre, and will be awarded a Double Doctorate degree in co-tutelle with the University of Veterinary Medicine and Pharmacy in Kosice (http://www.uvlf.sk/en), under the supervision of Professor Mangesh Bhide. The supervision team is completed by a non academic supervisor, Dr. Chris Chadwick, of Life Diagnostics (https://lifediagnostics.com/), UK.

The research will involve secondments to the University of Zagreb (http://www.unizg.hr/homepage/), Croatia, AB Agri (https://www.abagri.com/home) UK and MetLabs (http://metlabs.sk/), Slovak Republic.

The selected candidate will participate in the network’s training activities and work placements in the laboratories of the participating academic and industrial partners.

Eligibility criteria are indicated at admission rules page

For the specific ESR 4 position, it will be considered advantageous if the candidate has:

  • practical experience of animal handling
  • knowledge and experience of the regulations covering animal experimentation, though training for the required certification (Home Office Personal Licence) will be provided
  • experience of molecular science laboratory procedures

Shortlisted candidates for the ESR4 position will be required to complete the application process for the University of Glasgow.

The University of Glasgow requires the following additional documents at enrolment

  1. Final or current degree transcripts including grades (and an official translation, if needed) –scanned copy in colour of the original document
  2. Degree certificates (and an official translation, if needed): scanned copy in colour of the original document
  3. 2 references on headed paper (academic and/or professional).
  4. A certificate of English proficiency at the time of enrolment*

*English language proficiency certificate

For applicants whose first language is not English, the University sets a minimum English language proficiency level. A certificate of English proficiency at the time of enrolment is required such as IELTS (Academic) overall score 6.5 with no sub-test less than 6.0 and alternatives are listed at https://www.gla.ac.uk/international/englishlanguage/requirements. In certain circumstances a previous degree from an English speaking university may be accepted.

Proof of evidence for degree titles

  • Foreign academic degrees and diplomas should be validated and recognized by the authorized personnel of the University of Glasgow before enrolment in the PhD study

Benefits

Salary and other benefits for the ESR enrolled at the University of Glasgow are according to EU-standards for Marie Skłodowska-Curie Actions and national regulations. The living allowance will be €3741 per month (gross amount-subject to employers costs, as well as employees tax and insurance) and appointed ESR will be eligible to pay local tax and insurance. Additional benefits are possible in the case of family allowances which will be €500 per month.

Each ESR will also have a Research and Training allowance which will be managed through the University of Glasgow. This will cover the participation of researchers in training activities;

  • expenses related to research costs;
  • tuition fees (where applicable).
  • Visa, residency card for the recruited researcher and their family (where applicable)

A mobility allowance is also available. This will contribute to mobility related expenses of the ESR. The amount of the mobility allowance is specified in Table 1 of the MSCA Work Programme and for calls 2018-2020 and will amount to €600 per month.

Required documentation

Please refer to the general required documentation at https://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/

Application process

The deadline for application is 21st May 2018 through the completion of the form under the section ‘send your application‘.