TAGS: OMICs; miRNA; methyl-proteome;
The aim of the project is to evaluate the effects of increased Met intakes on metabolism and fertility in dairy cows during the first 140 d of lactation via characterizing the metabolome, the proteome and the microRNA-ome in blood serum.
Description of the project
The Early Stage Researcher (ESR) linked to the project will be involved in a large animal study with more than 1000 Holstein cows receiving a standard diet with or without Met supplementation from week 4 – 20 of lactation, and undergoing regular blood sampling. The ESR will use the performance (milk yield and composition), health and fertility data for identifying cows that are positively or negatively outstanding in terms of health, fertility and performance, to form 4 subgroups from which samples will be used. The analytical part comprises serum OMICS to characterize the metabolome, the phospho and the methyl-proteome and to assess miRNAs related to metabolic health and reproductive performance in blood serum from cows throughout the first 140 d of lactation. Besides, “classical” variables to describe the metabolic status and ovarian activity of the cows will be applied.
The ESR will be enrolled by the University of Bonn (https://www.uni-bonn.de/the-university) under the supervision of Prof. Helga Sauerwein and will be awarded a Double Doctorate degree in co-tutelle with the University of Glasgow (https://www.gla.ac.uk/) under the supervision of Dr Karl Burgess. The supervision team is completed by a non academic supervisor, Dr. Claudia Parys from Evonik Nutrition & Care GmbH (http://corporate.evonik.com/en), Germany.
The selected candidate will participate in the network’s training activities and work placements in the laboratories of the participating academic and industrial partners.