MANNA - project 10
10de it

Importance of supplying dairy cows with essential fatty acids (EFA) and conjugated linoleic acids (CLA) during the transition period on metabolism and health

Dr. Harald Hammon
Leibnitz Institute for Animal Biology (Germany)
https://www.fbn-dummerstorf.de/?L=1
MetLabs (Slovak Republic)
http://metlabs.sk/

TAGS: EFA; CLA; dairy cows;

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Objectives

The aim of the project is to test the effects of EFA and CLA alone and in combination in dairy cows receiving a fat-reduced diet.

Description of the project

The Early Stage Researcher (ESR) linked to the project will test the effects of EFA and CLA alone and in combination (abomasal application) in dairy cows receiving a fat-reduced diet. Beside recordings of performance, gas exchange (via respiration chambers) and ovarian cyclicity post partum, blood samples and liver biopsies will be collected. The calves born will be fed with their dams’ milk and blood sampled until day 5 of life will be collected. Blood and selected tissue and milk samples will be subjected to OMICs (metabolomics, proteomics, and transcriptomics, the latter focusing on circulating miRNA). The ESR will also quantify major metabolic hormones including the mRNA expression of their receptors in target tissues and markers of inflammation and oxidative stress in blood and milk.

The ESR will be enrolled by the University of Bonn (https://www.uni-bonn.de/the-university) under the supervision of Prof. Helga Sauerwein and will be awarded a Double Doctorate degree in co-tutelle with the University of Milan (http://www.unimi.it/) under the supervision of Prof. Fabrizio Ceciliani. The supervision team is completed by PD Dr. Harald Hammon, from the Leibnitz Institute for Animal Biology (https://www.fbn-dummerstorf.de/?L=1) at Dummerstorf, Germany.

The research will be involved in short secondments at INRA (http://www.ara.inra.fr/) in Clermont Ferrand, France, and MetLabs (http://metlabs.sk/) at Bratislava, Slovakia.

The selected candidate will participate in the network’s training activities and work placements in the laboratories of the participating academic and industrial partners.